Our Experience In Pmma Bone Cements Is Extensive. The Long ClinicalHeritage Of Our Depuy Cmw™ Bone Cement Product Range Has AllowedUs To Evaluate And Refine The Product Range Over Time. SmartsetBone Cements Are The Latest Cements In The Depuy Synthes Portfolio.Available In Medium And High Viscosity Formulations, With And WithoutGentamicin, Smartset Bone Cements Were Developed To Meet TheNeeds Of Today’s Orthopaedic Surgeons.Smartset Mv Endurance® Is A Medium Viscosity Bone CementWhich Was First Launched In 1995 As Endurance Bone Cement. It WasDeveloped To Give Surgeons A Medium Viscosity (Less Doughy) Cement.Smartset Hv Bone Cement Was First Launched In 2003 Together WithA Variant Of The Cement Containing The Active Substance Gentamicin.Smartset Hv Is A High Viscosity Bone Cement With HandlingCharacteristics Tailored To The Needs Of The Surgeon By Way Of A SlightlyLonger Setting Time Compared To Depuy Cmw 1 Bone Cement.
High Viscosity CementSmartset Hv Bone Cement Offers A Faster Pick-up Time ComparedTo Medium Viscosity Bone Cement And The Working Time Is Targeted AtCementing Procedures Which Require A Longer Working Time Such As AFully Cemented Total Knee Replacement. Smartset Hv Bone CementOffers An Overall Setting Time Of Approximately 13 ½ Minutes At 19°c(66°f).

Medium Viscosity CementSmartset Mv Endurance Bone Cement Combines The Benefits OfA Medium Viscosity Cement With Extended Working Time ComparedTo Depuy Cmw 3. Smartset Mv Endurance Bone Cement Sets InApproximately 16 ½ Minutes At 19°c (66°f).

Clinical Results Smartset Hv/smartset Ghv GentamicinBone CementSmartset Hv Has Been Studied Clinically: In A 2-year And 5-yearRadiostereometric Analysis (Rsa) Study.2,3 The Randomised ControlledStudy Lead By Prof. Otto Husby (St Olaf University Hospital, Trondheim,Norway) Used A Cemented Charnley Hip, Comparing Smartset Hv ToThe Outcome Of Palacos R. The Studies Concluded That: There Were NoStatistically Significant Differences In Migration3 And Fixation2 BetweenThe Smartset Hv Group And The Palacos R Group.The Graph Below Contains Data Relating To The Five Year Study ThatShows Translation Along The Y-axis Comparing Smartset Hv WithPalacos R. The Data Represents The Mean And 95% ConfidenceInterval (Ci) For The Pooled.

Gentamicin Antibiotic-loaded CementsIt Has Been Demonstrated In The Norwegian Arthroplasty RegistryThat Patients Receiving Antibiotic-loaded Bone Cement And SystemicAntibiotics Show Lower Revision Rates Than No Antibiotic Prophylaxis OrAntibiotic Cement On Its Own.4 Furthermore, Antibiotic Loaded BoneCement Is Proven To Reduce Infection Risk As Demonstrated In The ParviziEt Al Study On Primary Hip Replacement Which Showed That Antibiotic InThe Cement Provides Effective Prophylaxis Against Infection Leading ToAn Incidence Of Deep Infection Of Only 1.2% Compared To 2.3% WhenNo Antibiotic Was Used In The Bone Cement.5Bone Cement With Admixed Gentamicin Leads To Much Higher Levels OfGentamicin In The Joint Than Systemic Antibiotic Can Achieve.6 Therefore,Our Bone Cements Are Also Available With The Addition Of Gentamicin.Smartset Ghv Gentamicin Bone Cement And Smartset GmvEndurance Gentamicin Bone Cement Are Antibiotic-loaded With 1gActive Gentamicin In A Standard 40g Pack. Gentamicin Is Effective InReducing The Risks Presented By Gram-positive And A Few Gram-negativeBacteria.7 The Graph Displays The Most Relevant Micro-organismsAssociated With Infected Hip Replacement.In Vitro Testing Of Smartset Ghv Gentamicin Has Shown A Fast InitialElution Of Gentamicin, Typical Of Bone Cements Containing Antibiotic,With The Highest Cumulative Release Of Gentamicin Occurring Over TheFirst 24 Hours.8
This Fast Initial Elution Was Also Demonstrated In Vivo, WhereSmartset Ghv Gentamicin Was Tested With Regard To GentamicinRelease In Total Hip And Total Knee Replacement.9